Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys.

Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys.

PF-07209960 is a novel bispecific fusion protein composed of an anti-PD-1 antibody and engineered IL-15 cytokine mutein with reduced binding affinity to its receptors. The pharmacokinetics (PK), pharmacodynamics (PD), and toxicity of PF-07209960 were evaluated following once every other week subcuta...

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Bibliographic Details
Main Authors: Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0298240

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https://doi.org/10.1371/journal.pone.0298240

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