Chromatin regulators, phenotypic robustness and autism risk

Chromatin regulators, phenotypic robustness and autism risk

Though extensively characterized clinically, the causes of autism spectrum disorder (ASD) remain a mystery. ASD is known to have a strong genetic basis, but it is genetically very heterogeneous. Recent studies have estimated that de novo disruptive mutations in hundreds of genes may contribute to AS...

Full description

Bibliographic Details
Main Authors:	Reut eSuliman, Eyal eBen-David, Sagiv eShifman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-04-01
Series:	Frontiers in Genetics
Subjects:	Autism Spectrum Disorder de novo mutation chromatin regulators phenotypic robustness common genetic variants
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00081/full

Similar Items

Interactions of genetic risks for autism and the broad autism phenotypes
by: Lijie Dong, et al.
Published: (2023-03-01)

The Relevance of Variants With Unknown Significance for Autism Spectrum Disorder Considering the Genotype–Phenotype Interrelationship
by: Diogo V. Lovato, et al.
Published: (2019-06-01)

Case report: A novel frameshift mutation in BRSK2 causes autism in a 16-year old Chinese boy
by: Yu Hu, et al.
Published: (2023-08-01)

Mutations and modeling of the chromatin remodeler CHD8 define an emerging autism etiology
by: Rebecca A Barnard, et al.
Published: (2015-12-01)

Broad Autism Phenotype
by: Onder Kucuk, et al.
Published: (2018-06-01)

The evolution and mutational robustness of chromatin accessibility in Drosophila
by: Samuel Khodursky, et al.
Published: (2023-10-01)

Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability
by: Rajan K. C., et al.
Published: (2024-04-01)

A Machine Learning Approach to Predicting Autism Risk Genes: Validation of Known Genes and Discovery of New Candidates
by: Ying Lin, et al.
Published: (2020-09-01)

Challenges in screening for de novo noncoding variants contributing to genetically complex phenotypes
by: Christopher P. Castro, et al.
Published: (2023-07-01)

Histone variants shape chromatin states in Arabidopsis
by: Bhagyshree Jamge, et al.
Published: (2023-07-01)

Broader Autism Phenotype and Communication Skills in Parents of Children with Autism
by: Sepideh Yousefvand, et al.
Published: (2022-10-01)

De novo Mutations (DNMs) in Autism Spectrum Disorder (ASD): Pathway and Network Analysis
by: Aitana Alonso-Gonzalez, et al.
Published: (2018-09-01)

The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin
by: Truch, J, et al.
Published: (2022)

Measuring Social Camouflaging in Individuals with High Functioning Autism: A Literature Review
by: Ivan Mirko Cremone, et al.
Published: (2023-03-01)

Histone variants and chromatin structure, update of advances
by: Vladyslava Sokolova, et al.
Published: (2023-01-01)

Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders
by: Brennan H. Baker, et al.
Published: (2023-08-01)

Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
by: Karla Torres-Arciga, et al.
Published: (2022-11-01)

Insights from Initial Variant Detection by Sequencing Single Sperm in Cattle
by: Liu Yang, et al.
Published: (2021-11-01)

Exome sequencing reveals neurodevelopmental genes in simplex consanguineous Iranian families with syndromic autism
by: Mohammad-Reza Ghasemi, et al.
Published: (2024-08-01)

Expanding phenotype of MED13-associated syndrome presenting novel de novo missense variant in a patient with multiple congenital anomalies
by: Ekaterina Tolmacheva, et al.
Published: (2024-05-01)

Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study
by: Mona Abdi, et al.
Published: (2023-10-01)

Support for calcium channel gene defects in autism spectrum disorders
by: Lu Ake Tzu-Hui, et al.
Published: (2012-12-01)

A 'bottom-up' approach to aetiological research in autism spectrum disorders
by: Lisa Marie Unwin, et al.
Published: (2013-09-01)

Case Report: Expanded delineation of phenotype of TRPM3-related neurodevelopmental disorders
by: Agnieszka Pawelak, et al.
Published: (2024-11-01)

Exogenous attention to social stimuli in the neurotypical population: The impact of autism traits
by: F. Barros, et al.
Published: (2021-04-01)

Association of genetic variants with autism spectrum disorder in Japanese children revealed by targeted sequencing
by: Yuka Shiota, et al.
Published: (2024-08-01)

Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas
by: Xinyu Wang, et al.
Published: (2023-04-01)

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
by: Claudio Peter D’Incal, et al.
Published: (2023-03-01)

Exploring autistic traits in parents of autistic children: a pilot study on the broader autism phenotype
by: Antonio Narzisi, et al.
Published: (2025-03-01)

The role of aTp-dependent chromatin remodeling factors in chromatin assembly in vivo
by: Iu. A. Il’ina, et al.
Published: (2019-03-01)

The genetic landscape of autism spectrum disorder in the Middle Eastern population
by: Yasser Al-Sarraj, et al.
Published: (2024-03-01)

Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells
by: Nasna Nassir, et al.
Published: (2021-11-01)

Lost in Translation or Just Too Pragmatic? <subtitle>Validation of the German Broader Autism Phenotype Questionnaire (BAPQ-G)</subtitle>
by: Timo Lorenz, et al.
Published: (2021-12-01)

Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail
by: Brandon R Lowe, et al.
Published: (2021-02-01)

Behavioral phenotype and autism spectrum disorders in Cornelia de Lange syndrome
by: Lucia Parisi, et al.
Published: (2015-09-01)

A link between phenotypic robustness and life expectancy in Drosophila melanogaster
by: L. P. Zakharenko, et al.
Published: (2017-12-01)

Does the autism phenotype differ when selecting groups by neurodevelopmental versus genetic diagnosis? An observational study comparing autism and sex chromosome trisomy [version 1; peer review: 2 approved]
by: Dorothy V M Bishop, et al.
Published: (2022-05-01)

Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon
by: Roman Jaksik, et al.
Published: (2023-02-01)

Broad Autism Phenotype Questionnaire – Translation and Validation in a South Indian Language
by: Betsy Baby, et al.
Published: (2024-12-01)

Familiality of Quantitative Autism Traits
by: Katja Jussila, et al.
Published: (2015-05-01)