Partial Degradation of Recombinant Antibody Functional Activity During Infant Gastrointestinal Digestion: Implications for Oral Antibody Supplementation

Partial Degradation of Recombinant Antibody Functional Activity During Infant Gastrointestinal Digestion: Implications for Oral Antibody Supplementation

Oral administration of engineered immunoglobulins has the potential to prevent enteric pathogen-induced diarrhea in infants. To prevent infection, these antibodies need to survive functionally intact in the proteolytic environment of the gastrointestinal tract. This research examined both ex vivo an...

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Bibliographic Details
Main Authors: Baidya Nath P. Sah, Jiraporn Lueangsakulthai, Bum Jin Kim, Benjamin R. Hauser, Yeonhee Woo, Amy Olyaei, Molly Aloia, Ann O'Connor, Brian Scottoline, Manoj K. Pastey, David C. Dallas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Nutrition
Subjects:
palivizumab
infant digestion
human milk
antibody functional activity
respiratory syncytial virus
Online Access:https://www.frontiersin.org/article/10.3389/fnut.2020.00130/full

Internet

https://www.frontiersin.org/article/10.3389/fnut.2020.00130/full

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