Using observational study data as an external control group for a clinical trial: an empirical comparison of methods to account for longitudinal missing data

Using observational study data as an external control group for a clinical trial: an empirical comparison of methods to account for longitudinal missing data

Abstract Background Observational data are increasingly being used to conduct external comparisons to clinical trials. In this study, we empirically examined whether different methodological approaches to longitudinal missing data affected study conclusions in this setting. Methods We used data from...

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Bibliographic Details
Main Authors: Vibeke Norvang, Espen A. Haavardsholm, Sara K. Tedeschi, Houchen Lyu, Joseph Sexton, Maria D. Mjaavatten, Tore K. Kvien, Daniel H. Solomon, Kazuki Yoshida
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Medical Research Methodology
Subjects:
External control group
Missing data
Multiple imputation
Inverse probability weighting
Online Access:https://doi.org/10.1186/s12874-022-01639-0

Internet

https://doi.org/10.1186/s12874-022-01639-0

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