p53 SUMOylation Mediates AOPP-Induced Endothelial Senescence and Apoptosis Evasion

p53 SUMOylation Mediates AOPP-Induced Endothelial Senescence and Apoptosis Evasion

The aging of endothelial cells plays a critical role in the development of age-related vascular disease. We established a model of endothelial premature senescence by application of Advanced oxidation protein products (AOPPs) modified bovine serum albumin (AOPP-BSA) in human umbilical vein endotheli...

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Bibliographic Details
Main Authors: Yanjia Chen, Zhuanhua Liu, Hongyu Chen, Xingfu Huang, Xiaoxia Huang, Yang Lei, Qing Liang, Jiayi Wei, Qin Zhang, Xiaohua Guo, Qiaobing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
p53 SUMOylation
endothelial senescence
evasion of apoptosis
autophagy
vascular disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.795747/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.795747/full

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