CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors

CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors

The assembly of neurotransmitter receptors in the endoplasmic reticulum limits the number of receptors delivered to the plasma membrane, ultimately controlling neurotransmitter sensitivity and synaptic transfer function. In a forward genetic screen conducted in the nematode C. elegans, we identified...

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Bibliographic Details
Main Authors: Manuela D'Alessandro, Magali Richard, Christian Stigloher, Vincent Gache, Thomas Boulin, Janet E Richmond, Jean-Louis Bessereau
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
Cys-loop receptor
acetylcholine receptor (AChR)
neuromuscular junction (NMJ)
protein disulphide isomerase (PDI)
endoplasmic reticulum (ER)
Online Access:https://elifesciences.org/articles/39649

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https://elifesciences.org/articles/39649

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