Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Prostaglandin Metabolism and Increased Organic Anion Transport Protein (OATP) Expression

Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Prostaglandin Metabolism and Increased Organic Anion Transport Protein (OATP) Expression

Perfluorooctanesulfonate (PFOS) is a widespread environmental pollutant with a long half-life and clearly negative outcomes on metabolic diseases such as fatty liver disease and diabetes. Male and female Cyp2b-null and humanized CYP2B6-transgenic (hCYP2B6-Tg) mice were treated with 0, 1, or 10 mg/kg...

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Bibliographic Details
Main Authors: Lanie A. Williams, Matthew C. Hamilton, Matthew L. Edin, Fred B. Lih, Jazmine A. Eccles-Miller, Nishanth Tharayil, Elizabeth Leonard, William S. Baldwin
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Toxics
Subjects:
bioaccumulation
PFAS
OATP
transporters
oxylipins
prostaglandins
Online Access:https://www.mdpi.com/2305-6304/12/2/106

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https://www.mdpi.com/2305-6304/12/2/106

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