Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signaling is maintained, but insufficient for optimal en...

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Bibliographic Details
Main Authors: Luca Guglielmi, Claire Heliot, Sunil Kumar, Yuriy Alexandrov, Ilaria Gori, Foteini Papaleonidopoulou, Christopher Barrington, Philip East, Andrew D. Economou, Paul M. W. French, James McGinty, Caroline S. Hill
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26486-3

Internet

https://doi.org/10.1038/s41467-021-26486-3

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