Simultaneous editing of TCR, HLA-I/II and HLA-E resulted in enhanced universal CAR-T resistance to allo-rejection

Simultaneous editing of TCR, HLA-I/II and HLA-E resulted in enhanced universal CAR-T resistance to allo-rejection

IntroductionThe major challenge for universal chimeric antigen receptor T cell (UCAR-T) therapy is the inability to persist for a long time in patients leading to inferior efficacy clinically. The objective of this study was to design a novel UCAR-T cell that could avoid the occurrence of allo-rejec...

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Bibliographic Details
Main Authors: Wuling Li, Xiuxiu Zhu, Yanmin Xu, Jun Chen, Hongtao Zhang, Zhi Yang, Yanan Qi, Juan Hong, Yunyan Li, Guixue Wang, Junjie Shen, Cheng Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
universal CAR
CRISPR/Cas9
ETUCAR-T
natural killer cell
HLA-E
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1052717/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1052717/full

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