Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Glucose utilization increases in tumors, a metabolic process that is observed clinically by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are implicated in vivo? In a genetically-engineered mo...

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Bibliographic Details
Main Authors: Caroline Contat, Pierre-Benoit Ancey, Nadine Zangger, Silvia Sabatino, Justine Pascual, Stéphane Escrig, Louise Jensen, Christine Goepfert, Bernard Lanz, Mario Lepore, Rolf Gruetter, Anouk Rossier, Sabina Berezowska, Christina Neppl, Inti Zlobec, Stéphanie Clerc-Rosset, Graham William Knott, Jeffrey C Rathmell, E Dale Abel, Anders Meibom, Etienne Meylan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
genetically engineered mouse model of cancer
glucose transporters
lamellar bodies
lung adenocarcinoma
NanoSIMS
Online Access:https://elifesciences.org/articles/53618

Internet

https://elifesciences.org/articles/53618

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