Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors.

Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors.

BACKGROUND:Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Five...

Full description

Bibliographic Details
Main Authors: Karl Emil Nelveg-Kristensen, Peter Bie, Laura Ferrero, Ditte Bjerre, Niels E Bruun, Martin Egfjord, Henrik B Rasmussen, Peter R Hansen, INDICES Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5035013?pdf=render

Internet

http://europepmc.org/articles/PMC5035013?pdf=render

Similar Items