Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats

Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats

The accelerated blood clearance (ABC) phenomenon which is induced by repeated injection of poly (ethylene glycol) (PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response. A novel 4-arm poly (et...

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Bibliographic Details
Main Authors: Yuqing Su, Wenya Tang, Yanzhi Song, Chunling Wang, Qingjing Tian, Xuling Wang, Jingjing Quan, Buoqun Li, Shaoning Wang, Yihui Deng
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Accelerated blood clearance (ABC) phenomenon
Repeated administration
4-arm PEG5000-CHMA
Anti-PEG IgM
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300538

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http://www.sciencedirect.com/science/article/pii/S1818087616300538

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