Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats
The accelerated blood clearance (ABC) phenomenon which is induced by repeated injection of poly (ethylene glycol) (PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response. A novel 4-arm poly (et...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087616300538 |
| _version_ | 1818520615603142656 |
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| author | Yuqing Su Wenya Tang Yanzhi Song Chunling Wang Qingjing Tian Xuling Wang Jingjing Quan Buoqun Li Shaoning Wang Yihui Deng |
| author_facet | Yuqing Su Wenya Tang Yanzhi Song Chunling Wang Qingjing Tian Xuling Wang Jingjing Quan Buoqun Li Shaoning Wang Yihui Deng |
| author_sort | Yuqing Su |
| collection | DOAJ |
| description | The accelerated blood clearance (ABC) phenomenon which is induced by repeated injection of poly (ethylene glycol) (PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response. A novel 4-arm poly (ethylene glycol-5000)4-cholesteryl methyl amide (4-arm PEG5000-CHMA) has been synthesized. The structure of 4-arm PEG5000-CHMA was confirmed by IR and 1H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate (TN)-loaded nanoemulsions modified with 4-arm PEG5000-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000] (mPEG2000-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG5000-CHMA and mPEG2000-DSPE (CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, respectively. The circulation time of the CPNEs were comparable to the mPEG2000-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose. |
| first_indexed | 2024-12-11T01:39:50Z |
| format | Article |
| id | doaj.art-c3b0677954f6496988038f5d0d995076 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-11T01:39:50Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-c3b0677954f6496988038f5d0d9950762022-12-22T01:25:04ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762017-01-01121283610.1016/j.ajps.2016.07.003Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in ratsYuqing Su0Wenya Tang1Yanzhi Song2Chunling Wang3Qingjing Tian4Xuling Wang5Jingjing Quan6Buoqun Li7Shaoning Wang8Yihui Deng9School of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaBeijing Sihuan-Pharm Company, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, ChinaThe accelerated blood clearance (ABC) phenomenon which is induced by repeated injection of poly (ethylene glycol) (PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response. A novel 4-arm poly (ethylene glycol-5000)4-cholesteryl methyl amide (4-arm PEG5000-CHMA) has been synthesized. The structure of 4-arm PEG5000-CHMA was confirmed by IR and 1H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate (TN)-loaded nanoemulsions modified with 4-arm PEG5000-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000] (mPEG2000-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG5000-CHMA and mPEG2000-DSPE (CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, respectively. The circulation time of the CPNEs were comparable to the mPEG2000-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose.http://www.sciencedirect.com/science/article/pii/S1818087616300538Accelerated blood clearance (ABC) phenomenonRepeated administration4-arm PEG5000-CHMAAnti-PEG IgM |
| spellingShingle | Yuqing Su Wenya Tang Yanzhi Song Chunling Wang Qingjing Tian Xuling Wang Jingjing Quan Buoqun Li Shaoning Wang Yihui Deng Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats Asian Journal of Pharmaceutical Sciences Accelerated blood clearance (ABC) phenomenon Repeated administration 4-arm PEG5000-CHMA Anti-PEG IgM |
| title | Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats |
| title_full | Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats |
| title_fullStr | Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats |
| title_full_unstemmed | Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats |
| title_short | Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats |
| title_sort | mixed pegylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats |
| topic | Accelerated blood clearance (ABC) phenomenon Repeated administration 4-arm PEG5000-CHMA Anti-PEG IgM |
| url | http://www.sciencedirect.com/science/article/pii/S1818087616300538 |
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