An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Abstract Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear. Here we show that c-terminal Tyr 530 is a de facto c-Src autophosphorylatio...

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Bibliographic Details
Main Authors: Hipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, Jana Sánchez-Wandelmer, Wayland Yeung, Ana Martín-Hurtado, Inés G. Muñoz, Natarajan Kannan, Marta Llimargas, Javier Muñoz, Iván Plaza-Menacho
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41890-7

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https://doi.org/10.1038/s41467-023-41890-7

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