Arabinoxylans-Based Oral Insulin Delivery System Targeting the Colon: Simulation in a Human Intestinal Microbial Ecosystem and Evaluation in Diabetic Rats

Arabinoxylans-Based Oral Insulin Delivery System Targeting the Colon: Simulation in a Human Intestinal Microbial Ecosystem and Evaluation in Diabetic Rats

Arabinoxylans (AX) microcapsules loaded with insulin were prepared by enzymatic gelation of AX, using a triaxial electrospray method. The microcapsules presented a spherical shape, with an average size of 250 µm. The behavior of AX microcapsules was evaluated using a simulator of the human intestina...

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Bibliographic Details
Main Authors: Ana L. Martínez-López, Elizabeth Carvajal-Millan, Rafael Canett-Romero, Satya Prakash, Agustín Rascón-Chu, Yolanda L. López-Franco, Jaime Lizardi-Mendoza, Valerie Micard
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
insulin
oral drug delivery
electrospray
bioavailability
colon
SHIME
Online Access:https://www.mdpi.com/1424-8247/15/9/1062

Internet

https://www.mdpi.com/1424-8247/15/9/1062

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