Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We revie...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/9/2/16 |
| _version_ | 1797708082400198656 |
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| author | Jay B. Lusk Vanessa Y. M. Lam Nicholas S. Tolwinski |
| author_facet | Jay B. Lusk Vanessa Y. M. Lam Nicholas S. Tolwinski |
| author_sort | Jay B. Lusk |
| collection | DOAJ |
| description | EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer. |
| first_indexed | 2024-03-12T06:17:07Z |
| format | Article |
| id | doaj.art-c3b408cc14904607889e555648108220 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:17:07Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c3b408cc14904607889e5556481082202023-09-03T02:32:05ZengMDPI AGCancers2072-66942017-02-01921610.3390/cancers9020016cancers9020016Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding CancerJay B. Lusk0Vanessa Y. M. Lam1Nicholas S. Tolwinski2Division of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeDivision of Science, Yale-NUS College, Singapore 138527, SingaporeEGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer.http://www.mdpi.com/2072-6694/9/2/16EGF signalingDrosophila developmentRASRAFMAP kinaseMEK |
| spellingShingle | Jay B. Lusk Vanessa Y. M. Lam Nicholas S. Tolwinski Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer Cancers EGF signaling Drosophila development RAS RAF MAP kinase MEK |
| title | Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer |
| title_full | Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer |
| title_fullStr | Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer |
| title_full_unstemmed | Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer |
| title_short | Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer |
| title_sort | epidermal growth factor pathway signaling in drosophila embryogenesis tools for understanding cancer |
| topic | EGF signaling Drosophila development RAS RAF MAP kinase MEK |
| url | http://www.mdpi.com/2072-6694/9/2/16 |
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