Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix

Summary: Ectodomain (EC) shedding defines the proteolytic removal of a membrane protein EC and acts as an important molecular switch in signaling and other cellular processes. Using tumor necrosis factor (TNF)α as a model substrate, we identify a non-canonical shedding activity of SPPL2a, an intrame...

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Bibliographic Details
Main Authors: Charlotte Spitz, Christine Schlosser, Nadja Guschtschin-Schmidt, Walter Stelzer, Simon Menig, Alexander Götz, Martina Haug-Kröper, Christina Scharnagl, Dieter Langosch, Claudia Muhle-Goll, Regina Fluhrer
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Biochemistry
Structural Biology
Biophysics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030972X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422030972X

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