Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet

Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet

The transient receptor potential canonical channel 1 (TRPC1) is a ubiquitous Ca2+-permeable integral membrane protein present in most tissues, including adipose and placenta, and functionally regulates energetic homeostasis. We demonstrated that elimination of TRPC1 in a mouse model increased body a...

Full description

Bibliographic Details
Main Authors: Michael R. Bukowski, Brij B. Singh, James N. Roemmich, Kate J. Claycombe-Larson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Endocrinology
Subjects:
infusion lipidomics
placental lipidome
TRPC1
sphingolipid metabolism
triacylglycerol
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.854269/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.854269/full

Similar Items