Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs

Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs

The naturally occurring structure and biological functions of RNA are correlated, which includes hammerhead ribozymes. We proposed new variants of hammerhead ribozymes targeting conserved structural motifs of segment 5 of influenza A virus (IAV) (+)RNA. The variants carry structural and chemical mod...

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Bibliographic Details
Main Authors: Tomasz Czapik, Julita Piasecka, Ryszard Kierzek, Elzbieta Kierzek
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: oligonucleotides: therapies and applications
hammerhead ribozyme
influenza virus
RNA secondary structure
RNA conserved structural motifs
modified nucleosides
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001482

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http://www.sciencedirect.com/science/article/pii/S2162253122001482

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