The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes. However, there is currently limited knowledge on the immunogenicity of gametocyte antigens and the specificit...

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Bibliographic Details
Main Authors: Roos M. de Jong, Manon Alkema, Tate Oulton, Elin Dumont, Karina Teelen, Rie Nakajima, Rafael Ramiro de Assis, Kathleen W. Dantzler Press, Priscilla Ngotho, Kevin K.A. Tetteh, Phil Felgner, Matthias Marti, Katharine A. Collins, Chris Drakeley, Teun Bousema, Will J.R. Stone
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
malaria
Plasmodium falciparum
sexual stage
gametocyte antigens
antibody responses
controlled human malaria infection (CHMI)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.930956/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.930956/full

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