Molecular Insights into the Specific Targeting of <i>c-MYC</i> G-Quadruplex by Thiazole Peptides

Molecular Insights into the Specific Targeting of <i>c-MYC</i> G-Quadruplex by Thiazole Peptides

Stabilization of a G-quadruplex (G4) in the promotor of the <i>c-MYC</i> proto-oncogene leads to inhibition of gene expression, and it thus represents a potentially attractive new strategy for cancer treatment. However, most G4 stabilizers show little selectivity among the many G4s prese...

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Bibliographic Details
Main Authors: Sen Cao, Qian Su, Yong-Hao Chen, Meng-Lu Wang, Yi Xu, Li-Hui Wang, Yan-Hua Lu, Jian-Feng Li, Jun Liu, Xiao-Jing Hong, Hong-Yan Wang, Jun-Ping Liu, Zhi-Guo Wang
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
oncogene promotor
<i>c-MYC</i>
G-quadruplex
thiazole peptide
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/25/1/623

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https://www.mdpi.com/1422-0067/25/1/623

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