Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF).

The pineal gland, a circumventricular organ, plays an integrative role in defense responses. The injury-induced suppression of the pineal gland hormone, melatonin, which is triggered by darkness, allows the mounting of innate immune responses. We have previously shown that cultured pineal glands, wh...

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Bibliographic Details
Main Authors: Sanseray da Silveira Cruz-Machado, Luciana Pinato, Eduardo Koji Tamura, Cláudia Emanuele Carvalho-Sousa, Regina P Markus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3388049?pdf=render