The effect of DNA-dependent protein kinase on adeno-associated virus replication.

DNA-dependent protein kinase (DNA-PK) is a DNA repair enzyme and plays an important role in determining the molecular fate of the rAAV genome. However, the effect this cellular enzyme on rAAV DNA replication remains elusive.In the present study, we characterized the roles of DNA-PK on recombinant ad...

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Bibliographic Details
Main Authors: Young-Kook Choi, Kevin Nash, Barry J Byrne, Nicholas Muzyczka, Sihong Song
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3004791?pdf=render