Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains

Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains

ABSTRACT Prime-boost vaccinations of humans with different H5 strains have generated broadly protective antibody levels. However, the effect of an individual’s H5 exposure history on antibody responses to subsequent H5 vaccination is poorly understood. To investigate this, we analyzed the IgG respon...

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Bibliographic Details
Main Authors: Jiong Wang, Dongmei Li, Sheldon Perry, Shannon P. Hilchey, Alexander Wiltse, John J. Treanor, Mark Y. Sangster, Martin S. Zand
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
H5 monovalent influenza vaccine (MIV)
hemagglutinin (HA) antigenic distance
influenza virus antibody landscape
original antigenic sin (OAS)
HA imprinting
Online Access:https://journals.asm.org/doi/10.1128/mBio.00449-21

Internet

https://journals.asm.org/doi/10.1128/mBio.00449-21

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