PRMT5: An Emerging Target for Pancreatic Adenocarcinoma

PRMT5: An Emerging Target for Pancreatic Adenocarcinoma

The overall survival of pancreatic ductal adenocarcinoma (PDAC) remains poor and its incidence is rising. Targetable mutations in PDAC are rare, thus novel therapeutic approaches are needed. Protein arginine methyltransferase 5 (PRMT5) overexpression is associated with worse survival and inhibition...

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Bibliographic Details
Main Authors: Michael K. C. Lee, Sean M. Grimmond, Grant A. McArthur, Karen E. Sheppard
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
PRMT5
protein methyltransferase
pancreatic adenocarcinoma
alternative splicing
FBXW7
c-Myc
Online Access:https://www.mdpi.com/2072-6694/13/20/5136

Internet

https://www.mdpi.com/2072-6694/13/20/5136

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