Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing
Abstract 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are modified versions of cytosine in DNA with roles in regulating gene expression. Using whole genomic DNA from mouse cerebellum, we benchmark 5mC and 5hmC detection by Oxford Nanopore Technologies sequencing against other standard t...
| Glavni autori: | , , , , |
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| Format: | Članak |
| Jezik: | English |
| Izdano: |
Nature Portfolio
2025-02-01
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| Serija: | Communications Biology |
| Online pristup: | https://doi.org/10.1038/s42003-025-07681-0 |