ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Abstract Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that...

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Bibliographic Details
Main Authors: Guiwen Ye, Jinteng Li, Wenhui Yu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Shan Wang, Qian Cao, Jiajie Lin, Zepeng Su, Dateng Li, Yunshu Che, Shuai Fan, Peng Wang, Yanfeng Wu, Huiyong Shen
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-01059-0

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https://doi.org/10.1038/s12276-023-01059-0

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