ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Abstract Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that...

Full description

Bibliographic Details
Main Authors:	Guiwen Ye, Jinteng Li, Wenhui Yu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Shan Wang, Qian Cao, Jiajie Lin, Zepeng Su, Dateng Li, Yunshu Che, Shuai Fan, Peng Wang, Yanfeng Wu, Huiyong Shen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-08-01
Series:	Experimental and Molecular Medicine
Online Access:	https://doi.org/10.1038/s12276-023-01059-0

Similar Items

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis
by: Li Jinteng, et al.
Published: (2023-03-01)

Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
by: Jinteng Li, et al.
Published: (2023-08-01)

Correction: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade
by: Jinteng Li, et al.
Published: (2023-09-01)

Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation
by: Zhengyu Qian, et al.
Published: (2023-08-01)

The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment
by: Zhaoqiang Zhang, et al.
Published: (2023-03-01)

ALKBH1‐mediated m1A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression
by: Wenwen Chen, et al.
Published: (2023-02-01)

K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis
by: Xiao-Lan Zhang, et al.
Published: (2023-06-01)

ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma
by: Shuo Chen, et al.
Published: (2020-01-01)

ALKBH5-mediated m6A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression
by: Yuting Tang, et al.
Published: (2023-10-01)

LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells
by: Jiajie Lin, et al.
Published: (2022-09-01)

Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells
by: Pranjal Sarma, et al.
Published: (2020-10-01)

Aberrantly Expressed lncRNAs and mRNAs of Osteogenically Differentiated Mesenchymal Stem Cells in Ossification of the Posterior Longitudinal Ligament
by: Zhaopeng Cai, et al.
Published: (2020-08-01)

ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
by: Xin Huang, et al.
Published: (2023-07-01)

ALKBH5‐mediated m6A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma
by: Yuhan Chen, et al.
Published: (2023-02-01)

TNF‐α‐Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy‐Related Protein VCP
by: Zepeng Su, et al.
Published: (2024-03-01)

Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis
by: Yu Wenhui, et al.
Published: (2022-05-01)

ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription
by: Leilei Liang, et al.
Published: (2022-08-01)

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes
by: Kaur, S, et al.
Published: (2022)

Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia
by: Ben Yue, et al.
Published: (2021-12-01)

The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway
by: Yi Zhang, et al.
Published: (2022-09-01)

Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer
by: Li Y, et al.
Published: (2022-05-01)

High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for diabetic cognitive dysfunction
by: Minli Qu, et al.
Published: (2023-06-01)

Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
by: Wenhui Yu, et al.
Published: (2023-06-01)

Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis
by: Wenhui Yu, et al.
Published: (2023-06-01)

lncRNA-mRNA expression profiles and functional networks of mesenchymal stromal cells involved in monocyte regulation
by: Ming Li, et al.
Published: (2019-07-01)

M6A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer
by: Xi Liu, et al.
Published: (2024-02-01)

ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma
by: Wenhui Tang, et al.
Published: (2022-12-01)

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification
by: Yiyang Hu, et al.
Published: (2022-02-01)

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression
by: Mayumi Hirayama, et al.
Published: (2020-04-01)

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
by: Aik, W, et al.
Published: (2014)

ALKBH5-Mediated m6A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy
by: Tingting Chen, et al.
Published: (2022-03-01)

m6A eraser ALKBH5 mitigates the apoptosis of cardiomyocytes in ischemia reperfusion injury through m6A/SIRT1 axis
by: Liangliang Liu, et al.
Published: (2023-05-01)

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
by: Yunhao Chen, et al.
Published: (2020-08-01)

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
by: Aik, W, et al.
Published: (2014)

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation
by: Xinyu Bian, et al.
Published: (2021-03-01)

Regulatory factor X1 induces macrophage M1 polarization by promoting DNA demethylation in autoimmune inflammation
by: Shuang Yang, et al.
Published: (2023-10-01)

Targeted mRNA demethylation in Arabidopsis using plant m6A editor
by: Ruiqiu Fang, et al.
Published: (2023-08-01)

Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
by: Xu, C, et al.
Published: (2014)

Bifunctional Role of Fe(II)/2OG-Dependent TET Family 5-Methylcytosine Dioxygenases and ALKBH2,3 in Modified Cytosine Demethylation
by: Aninda Sundar Dey
Published: (2022-07-01)

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota
by: Zheng-Wei Zhang, et al.
Published: (2021-10-01)