Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice.

Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice.

With the rapid progress made in the development of vaccines to fight the SARS-CoV-2 pandemic, almost >90% of vaccine candidates under development and a 100% of the licensed vaccines are delivered intramuscularly (IM). While these vaccines are highly efficacious against COVID-19 disease, their eff...

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Bibliographic Details
Main Authors: Shyamala Ganesan, Hugo Acosta, Chris Brigolin, Kallista Orange, Kevin Trabbic, Charles Chen, Chia-En Lien, Yi-Jiun Lin, Meei-Yun Lin, Ya-Shan Chuang, Ali Fattom, Vira Bitko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0272594

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https://doi.org/10.1371/journal.pone.0272594

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