Keratinocytes and Activation of TREM-1 Pathway in Cutaneous Leishmaniasis Lesions

Keratinocytes and Activation of TREM-1 Pathway in Cutaneous Leishmaniasis Lesions

Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) amplifies the immune response, operating synergistically with Toll-Like Receptors (TLRs) in the production of inflammatory mediators. TREM-1 signaling depends on the adapter protein DAP12, which results in the activation of NFkB, the expressi...

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Bibliographic Details
Main Authors: Sara Nunes, Mariana Rosa Ampuero, Ícaro Bonyek-Silva, Reinan Lima, Filipe Rocha Lima, Sérgio Marcos Arruda, Ricardo Khouri, Pablo Rafael Silveira Oliveira, Aldina Barral, Viviane Sampaio Boaventura, Cláudia Ida Brodskyn, Natalia Machado Tavares
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Microbiology Research
Subjects:
<i>Leishmania</i>
inflammation
TREM-1
keratinocytes
Online Access:https://www.mdpi.com/2036-7481/12/4/56

Internet

https://www.mdpi.com/2036-7481/12/4/56

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