Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer

Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer

SIRT5 is a mitochondrial NAD+ -dependent lysine deacylase. Downregulation of SIRT5 has been linked to several primary cancers and DNA damage. In clinical therapy for non-small cell lung cancer (NSCLC), the Feiyiliu Mixture (FYLM) is an experience and effective Chinese herb prescription. And we found...

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Bibliographic Details
Main Authors: Baochen Zhou, Ye Yang, Xuemeng Pang, Jingjing Shi, Ting Jiang, Xin Zheng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Quercetin
SIRT5
PI3K/AKT
NSCLC
DDR
Mitotic catastrophe
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223008624

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http://www.sciencedirect.com/science/article/pii/S0753332223008624

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