Therapeutic potential of LINS01 histamine H3 receptor antagonists as antineoplastic agents for triple negative breast cancer

Therapeutic potential of LINS01 histamine H3 receptor antagonists as antineoplastic agents for triple negative breast cancer

The aims of this work were to evaluate the expression of histamine H3 receptor (H3R) in triple negative breast cancer (TNBC) samples and to investigate the antitumoral efficacy and safety of the LINS01 series of H3R antagonists, through in silico, in vitro, and in vivo approaches. Antitumor activity...

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Bibliographic Details
Main Authors: Ignacio A. Ospital, Mónica A. Táquez Delgado, Melisa B. Nicoud, Michelle F. Corrêa, Gustavo A. Borges Fernandes, Isabela W. Andrade, Paolo Lauretta, Rocío Martínez Vivot, María Betina Comba, María Marta Zanardi, Daniela Speisky, Juan L. Uriburu, João P.S. Fernandes, Vanina A. Medina
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Target therapy
Histamine H3 receptor
Breast cancer
Cell proliferation
ADMET
Methyl piperazines
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004116

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http://www.sciencedirect.com/science/article/pii/S0753332224004116

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