Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice

This study was designed to improve the efficacy of radiation therapy against radiation-resistant leukemia. We report that the potency of low dose radiation therapy against B-precursor acute lymphoblastic leukemia (BPL) can be markedly enhanced by combining radiation with a liposomal nanoparticle (LN...

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Bibliographic Details
Main Authors: Fatih M. Uckun, Dorothea E. Myers, Jianjun Cheng, Sanjive Qazi
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:EBioMedicine
Subjects:
Leukemia
Bone marrow transplantation
Total body irradiation
Radiation resistance
Personalized medicine
Precision medicine
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000997

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http://www.sciencedirect.com/science/article/pii/S2352396415000997

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