A deep learning approach to real-time Markov modeling of ion channel gating

Abstract The patch-clamp technique allows us to eavesdrop the gating behavior of individual ion channels with unprecedented temporal resolution. The signals arise from conformational changes of the channel protein as it makes rapid transitions between conducting and non-conducting states. However, u...

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Bibliographic Details
Main Authors: Efthymios Oikonomou, Yannick Juli, Rajkumar Reddy Kolan, Linda Kern, Thomas Gruber, Christian Alzheimer, Patrick Krauss, Andreas Maier, Tobias Huth
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01369-y