Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

Abstract Background The evolution of drug resistance is one of the biggest challenges in leishmaniasis and has prompted the need for new antileishmanial drugs. Repurposing of approved drugs is a faster and very attractive strategy that is gaining supporters worldwide. Different anticancer topoisomer...

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Bibliographic Details
Main Authors: Chloé Rosa-Teijeiro, Victoria Wagner, Audrey Corbeil, Ilda d’Annessa, Philippe Leprohon, Rubens L. do Monte-Neto, Christopher Fernandez-Prada
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Parasites & Vectors
Subjects:
Protozoan parasites
Leishmania
DNA topoisomerases
Topotecan
Drug resistance
SNPs
Online Access:https://doi.org/10.1186/s13071-021-04947-4

Internet

https://doi.org/10.1186/s13071-021-04947-4

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