Mechanism of curaxin-dependent nucleosome unfolding by FACT

Mechanism of curaxin-dependent nucleosome unfolding by FACT

Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c-trapping) through an unknown molecular mechanism....

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Bibliographic Details
Main Authors: Olesya I. Volokh, Anastasia L. Sivkina, Andrey V. Moiseenko, Anna V. Popinako, Maria G. Karlova, Maria E. Valieva, Elena Y. Kotova, Mikhail P. Kirpichnikov, Timothy Formosa, Vasily M. Studitsky, Olga S. Sokolova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
SPT16
FACT
SSRP1
nucleosome
transmission electron microscopy
SpFRET microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1048117/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.1048117/full

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