Mechanism of curaxin-dependent nucleosome unfolding by FACT
Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c-trapping) through an unknown molecular mechanism....
| Κύριοι συγγραφείς: | , , , , , , , , , , |
|---|---|
| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
Frontiers Media S.A.
2022-11-01
|
| Σειρά: | Frontiers in Molecular Biosciences |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1048117/full |