Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation

Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation

ABSTRACT K2-capsular Klebsiella pneumoniae is a hypervirulent pathogen that causes fatal infections. Here, we describe a phage tailspike protein, named K2-2, that specifically depolymerizes the K2 capsular polysaccharide (CPS) of K. pneumoniae into tetrasaccharide repeating units. Nearly half of the...

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Bibliographic Details
Main Authors: Ting-Juan Ye, Kit-Man Fung, I-Ming Lee, Tzu-Ping Ko, Chia-Yi Lin, Chia-Ling Wong, I-Fan Tu, Tzu-Yin Huang, Feng-Ling Yang, Yu-Pei Chang, Jin-Town Wang, Tzu-Lung Lin, Kai-Fa Huang, Shih-Hsiung Wu
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
Klebsiella pneumonia
bacteriophage
tailspike protein
O-acetylation
intersubunit carbohydrate-binding site
Online Access:https://journals.asm.org/doi/10.1128/mbio.03519-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03519-23

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