Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease

Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease

ObjectivesGraves' disease (GD) with onset in childhood or adolescence is a rare disease (ORPHA:525731). Current pharmacotherapeutic approaches use antithyroid drugs, such as carbimazole, as monotherapy or in combination with thyroxine hormone substitutes, such as levothyroxine, as block-and-rep...

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Bibliographic Details
Main Authors: Britta Steffens, Gilbert Koch, Pascal Gächter, Fabien Claude, Verena Gotta, Freya Bachmann, Johannes Schropp, Marco Janner, Dagmar l'Allemand, Daniel Konrad, Tatjana Welzel, Gabor Szinnai, Marc Pfister
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Medicine
Subjects:
Graves' disease (GD)
pediatric rare diseases
hyperthyroidism
thyrotoxicosis
carbimazole monotherapy
block-and-replace therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1099470/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1099470/full

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