A Noisy Analog-to-Digital Converter Connects Cytosolic Calcium Bursts to Transcription Factor Nuclear Localization Pulses in Yeast

A Noisy Analog-to-Digital Converter Connects Cytosolic Calcium Bursts to Transcription Factor Nuclear Localization Pulses in Yeast

Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz1 follow stochastic variations in cytosolic calcium concentra...

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Bibliographic Details
Main Authors: Ian S. Hsu, Bob Strome, Sergey Plotnikov, Alan M. Moses
Format: Article
Language:English
Published: Oxford University Press 2019-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
stochastic pulsing transcription factor
Crz1
time delay model
mathematical modelling
calcineurin pathway
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200841

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200841

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