Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation

Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation

α-Synuclein is a 140 amino-acid intrinsically disordered protein mainly found in the brain. Toxic α-synuclein aggregates are the molecular hallmarks of Parkinson’s disease. In vitro studies showed that α-synuclein aggregates in oligomeric structures of several 10th of monomers and into cylindrical s...

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Bibliographic Details
Main Authors: Adrien Guzzo , Patrice Delarue , Ana Rojas, Adrien Nicolaï , Gia G. Maisuradze , Patrick Senet
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
α-synuclein
amyloid
Parkinson’s disease
molecular dynamics
dimers
CUTABI
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.910104/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.910104/full

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