Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Abstract Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8+ T cells, is regulated by several intrinsic signaling pathways. Here, we found that tobacco smoke, a major public health concern that kills 8...

Full description

Bibliographic Details
Main Authors: Fan Liang, Gui-Zhen Wang, Yan Wang, Ya-Ning Yang, Zhe-Sheng Wen, Dong-Ni Chen, Wen-Feng Fang, Bin Zhang, Lu Yang, Chen Zhang, Si-Chong Han, Fu-Ying Yang, Di Wang, Li-Jun Liang, Zheng Wang, Yong Zhao, Chang-Li Wang, Li Zhang, Guang-Biao Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01127-3

Internet

https://doi.org/10.1038/s41392-022-01127-3

Similar Items