Matching amino acids membrane preference profile to improve activity of antimicrobial peptides

Canonical helical antimicrobial peptides are less insertive and less active. Here, an improved antimicrobial peptide, WCopWs, indicate that matching amino acids membrane preference profile improves insertion and activity.

Bibliographic Details
Main Authors: Shanghyeon Kim, Jaehoo Lee, Sol Lee, Hyein Kim, Ji-Yeong Sim, Boryeong Pak, Kyeongmin Kim, Jae Il Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04164-4