Elevated permeability of the blood–brain barrier in mice intratracheally administered porcine pancreatic elastase

Chronic obstructive pulmonary disease (COPD) shows progressive, irreversible airflow limitation induced by emphysema and lung inflammation. The aim of the present study was to determine if COPD conditions induce blood–brain barrier (BBB) dysfunction. We found that the intratracheal administration of...

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Bibliographic Details
Main Authors: Fuyuko Takata, Koji Tominaga, Mitsuhisa Koga, Shinya Dohgu, Koujiro Futagami, Atsushi Yamauchi, Yasufumi Kataoka
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001917