Screening and identification of potential MERS-CoV papain-like protease (PLpro) inhibitors; Steady-state kinetic and Molecular dynamic studies

Screening and identification of potential MERS-CoV papain-like protease (PLpro) inhibitors; Steady-state kinetic and Molecular dynamic studies

MERS-CoV belongs to the coronavirus group. Recent years have seen a rash of coronavirus epidemics. In June 2012, MERS-CoV was discovered in the Kingdom of Saudi Arabia, with 2,591 MERSA cases confirmed by lab tests by the end of August 2022 and 894 deaths at a case-fatality ratio (CFR) of 34.5% docu...

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Bibliographic Details
Main Authors: Mohammed Ali Dahhas, Hamad M. Alkahtani, Ajamaluddin Malik, Abdulrahman A Almehizia, Ahmed H. Bakheit, Siddique Akber Ansar, Abdullah S. AlAbdulkarim, Lamees S.Alrasheed, Mohammad A. Alsenaidy
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Saudi Pharmaceutical Journal
Subjects:
MERS-CoV PLpro Inhibitors
Papain-like protease
Drug Design
Drug Discovery
Inhibitors
Nonstructural proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422003061

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http://www.sciencedirect.com/science/article/pii/S1319016422003061

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