Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human <i>Alu</i> Repeat Sequences

Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human <i>Alu</i> Repeat Sequences

Integrated HIV-1 DNA persists despite antiretroviral therapy and can fuel viral rebound following treatment interruption. Hence, methods to specifically measure the integrated HIV-1 DNA portion only are important to monitor the reservoir in eradication trials. Here, we provide an up-to-date overview...

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Bibliographic Details
Main Authors: Eva Malatinkova, Jordan Thomas, Ward De Spiegelaere, Sofie Rutsaert, Anna Maria Geretti, Georgios Pollakis, William A. Paxton, Linos Vandekerckhove, Alessandra Ruggiero
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Life
Subjects:
integrated HIV-1
<i>Alu</i>-gag
<i>Alu</i>-5LTR
quantification
reservoir
Online Access:https://www.mdpi.com/2075-1729/11/12/1410

Internet

https://www.mdpi.com/2075-1729/11/12/1410

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