Plasma Exosomal Mir-423-5p Is Involved in the Occurrence and Development of Bicuspid Aortopathy via TGF-β/SMAD2 Pathway

Plasma Exosomal Mir-423-5p Is Involved in the Occurrence and Development of Bicuspid Aortopathy via TGF-β/SMAD2 Pathway

Objectives: Patients with bicuspid aortic valve (BAV) are at increased risk for ascending aortic dilation (AAD). Our study was aimed at systemically analyzing the expression profile and mechanism of circulating plasma exosomal microRNAs (miRNAs) related to BAV and AAD.Methods: We isolated plasma exo...

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Bibliographic Details
Main Authors: Hongqiang Zhang, Dingqian Liu, Shichao Zhu, Fanshun Wang, Xiaoning Sun, Shouguo Yang, Chunsheng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Physiology
Subjects:
exosomal miRNA
bicuspid aortic valve
bicuspid aortopathy
TGF-β signaling
SMAD2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.759035/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.759035/full

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