Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia

Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia

Ras homolog enriched in striatum (Rhes) is a small GTP-binding protein that modulates signal transduction at dopamine receptors, and also activates mammalian target of rapamycin complex 1 (mTORC1). Rhes binding to mTORC1 is hypothesized to play a role in motor disorders such as levodopa-induced dysk...

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Bibliographic Details
Main Authors: Alberto Brugnoli, Francesco Napolitano, Alessandro Usiello, Michele Morari
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Neurobiology of Disease
Subjects:
Dyskinesia
GABA
Glutamate
Levodopa
mTORC1
Microdialysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300784

Internet

http://www.sciencedirect.com/science/article/pii/S0969996115300784

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