Gut microbiota alterations may increase the risk of prescription opioid use, but not vice versa: A two-sample bi-directional Mendelian randomization study

Gut microbiota alterations may increase the risk of prescription opioid use, but not vice versa: A two-sample bi-directional Mendelian randomization study

IntroductionGut microbiota alterations are strongly associated with prescription opioid use (POU) and multisite chronic pain (MCP). However, whether or not these associations are causal remains unknown. Therefore, we aim to explore the causal relationships between them comprehensively.MethodsA two-s...

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Bibliographic Details
Main Authors: Liling Lin, Jianwei Lin, Junxiong Qiu, Feng Wei, Xiaohui Bai, Weiying Ma, Jingxian Zeng, Daowei Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
causality
prescription opioid use
multisite chronic pain
gut microbiota
metabolites
Mendelian randomization
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.994170/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.994170/full

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