PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia

PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia

Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential due to their enhanced angiogenic and proliferative...

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Bibliographic Details
Main Authors: Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
NOX4 NADPH oxidase
placenta-specific 8
endothelial colony-forming cells
hypoxia
angiogenesis
reactive oxygen species
Online Access:https://www.mdpi.com/2073-4409/12/18/2220

Internet

https://www.mdpi.com/2073-4409/12/18/2220

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